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KMID : 0378119820090010013
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Chungnam Medical Journal
1982 Volume.9 No. 1 p.13 ~ p.23
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A Study of Immunosuppressive Effects of X-ray Irradiation, and Injection of Cytoxan and Imuran to the Mycobacterial
Antigen Inoculated Mice
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Abstract
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This study was done to determine whether it is possible to inoculate with Mycobacterium, which is characterized by prolonged life in culture and specific studies, to the mice which were immunosuppressed by X-ray irradiation and injection of Cytoxan and Imuran. The results are summarized as follows.
1. After 500r X-ray total body irradiation of the mice, the peripheral W. B. C. persisted under 4, 000/3 for 24 days.
2. Following alternative injection of Cytoxan and Imuran(O. lmg/g of body weight) for 4days, the peripheral W. B. C. persisted under 4, 000/xx3 for 9 days.
3. Following the irradiation (500r) with alternative injection of Cytoxan and Imuran (0.1mg/g body weight) for 4 days, the peripheral W. B. C. persisted under 4, 000/a3 for 28 days.
4. Following 3 days after the irradiation (500r), Mycobacterium ulcerans antigen were given to the mice. The peripheral W. B. C. increased over 4, 200/=3 9 days of to injection of the antigen.
As the above results show it was possible to produce immunosuppression in the mice for one month. So this method is acceptable in producing infection with mycobacterium which require relatively short duration of growth. But this methods is not acceptable in mycobacterium which require a long duration of growth.
Therefore it was considered recommendable another experimental method for producing infection in mice with Mycobacterium leper.
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